New Publications from the Mass General Department of Psychiatry – June 27, 2025

The Mass General Department of Psychiatry encompasses more than 60 specialty integrated clinical and research programs.  Our wide-ranging research portfolio spans clinical and basic research covering virtually every major psychiatric disorder, as well as the psychiatric consequences of medical illness. 

These initiatives have led to notable expansions in genetics, neuroimaging and basic neuroscience, and this model of cross-talk between clinical care and science has consistently led to research advances that inform and advance clinical care.

A mind-body resilience intervention for emotional distress in cardiac arrest survivors and their informal caregivers – Recovering together after cardiac arrest: Protocol for an open pilot trial.

La Camera D, Elmer J, Perman SM, Donnino MW, Wu O, Parker RA, Vranceanu AM, Presciutti AM.  Contemp Clin Trials Commun. 2025 Jan 2;43:101426. 

Improvements in pain interference among geographically diverse adults with neurofibromatosis: Results from a fully powered randomized controlled trial.

Hooker JE, Doorley JD, Greenberg J, Bakhshaie J, Manglani HR, Briskin EA, Vranceanu AM.  Neurooncol Pract. 2024 Sep 20;12(1):58-67. 

Research Priorities in Neuropalliative Care: A Consensus Statement From the International Neuropalliative Care Society.

Lau WK, Fehnel CR, Macchi ZA, Mehta AK, Auffret M, Bogetz JF, Fleisher JE, Graber JJ, Leeper HE, Manglani-Terranova HR, Muehlschlegel S, Mroz EL, Pedowitz EJ, Ramanathan U, Sarmet M, Shlobin NA, Sokol L, Weeks SA, Xu J, Bundy Medsger H, Creutzfeldt CJ, Vranceanu AM, Zahuranec DB, Hwang DY.  JAMA Neurol. 2025 Feb 3. 

Association of Cannabis Legalization With Prevalence of Schizophrenia-Challenges of Attributing Biological Causality to Policy Change.

Gilman JM.  JAMA Netw Open. 2025 Feb 3;8(2):e2457876. 

Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies.

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.  Cell. 2025 Feb 6;188(3):640-652.e9. 

Generative AI in a new era of computer model-informed tobacco research: a short report.

Vassey J, Kennedy CJ, Chang HH, Unger JB.  Tob Control. 2025 Feb 6:tc-2024-058887. 

Pilot Randomized Controlled Trial of the Feasibility of a Mobile App-Delivered Mindfulness-Based Intervention for Caregiver Stress.

Plys E, Seward M, Allen EM, Tatar RG, Huberty J, Vranceanu AM.  Gerontologist. 2025 Feb 8:gnaf047. 

Understanding adolescent mental health symptom progression in school-based settings: The Substance Use and Risk Factors (SURF) longitudinal survey.

Costello MA, Pascale M, Potter K, Knoll SJ, Bodolay A, Kaur J, Du R, Greenspan L, Gray CA, McIntyre J, Schuster RM.  Sch Psychol. 2025 Feb 10. 

Development of a Mindfulness and Self-compassion (MASC) Stress Reduction Program for Caregivers of Persons with Dementia with Behavioral Symptoms.

Stone SM, Giraldo-Santiago N, Miller A, O’Donnell A, Travis A, Ritchie CS, Vranceanu AM.

Gerontologist. 2025 Feb 10:gnaf058.

Instability of high polygenic risk classification and mitigation by integrative scoring.

Misra A, Truong B, Urbut SM, Sui Y, Fahed AC, Smoller JW, Patel AP, Natarajan P. Nat Commun. 2025 Feb 12;16(1):1584. 

Advancing Mental Health Research Through Strategic Integration of Transdiagnostic Dimensions and Genomics.

Doyle AE, Bearden CE, Gur RE, Ledbetter DH, Martin CL, McCoy TH Jr, Pasaniuc B, Perlis RH, Smoller JW, Davis LK.  Biol Psychiatry. 2025 Mar 1;97(5):450-460. 

Predictors of polyregulation and its effectiveness following exposure to One’s most personally distressing intrusive thought.

Daniel KE, Wilhelm S, Jacoby RJ.  J Behav Ther Exp Psychiatry. 2025 Mar;86:

Efficacy and safety of lemborexant in subjects with insomnia disorder receiving medications for depression or anxiety symptoms.

Krystal A, Blier P, Culpepper L, Nierenberg AA, Takaesu Y, Kubota N, Moline M, Malhotra M, Pinner K, Yardley J.  Neuropsychopharmacol Rep. 2025 Mar;45(1):e12509. 

Clinician Perspectives Highlight the Need for Early Dyadic Coping Skills for People Living With Amyotrophic Lateral Sclerosis.

Rush CL, Lyons C, Gittle J, Seward M, Scalia J, Ho D, Babu S, Garret MA, Brizzi K, Berry JD, Fava M, Lindenberger E, Vranceanu AM; Sean M. Healey and AMG Center for ALS Resilient Together-ALS (RT-ALS) Team.  J Pain Symptom Manage. 2025 Mar;69(3):236-242.e4. 

Statistical methods to adjust for the effects on intervention compliance in randomized clinical trials where precision treatment rules are being developed.

Zainal NH, Benjet C, Albor Y, Nuñez-Delgado M, Zambrano-Cruz R, Contreras-Ibáñez CC, Cudris-Torres L, de la Peña FR, González N, Guerrero-López JB, Gutierrez-Garcia RA, Jiménez-Peréz AL, Medina-Mora ME, Patiño P, Cuijpers P, Gildea SM, Kazdin AE, Kennedy CJ, Luedtke A, Sampson NA, Petukhova MV, Zubizarreta JR, Kessler RC.  Int J Methods Psychiatr Res. 2025 Mar;34(1):e70005. 

Electroconvulsive therapy in autism spectrum disorders: an update to the literature.

Wachtel L, Luccarelli J, Falligant JM, Smith JR.  Curr Opin Psychiatry. 2025 Mar 1;38(2):79-86. 

Challenges faced by patients undergoing fecal ostomy surgery: a qualitative study of colorectal cancer patient perspectives.

Soelling SJ, Rubio-Chavez A, Ingram Z, Baird L, Brindle ME, Cooper Z, Vranceanu AM, Ritchie CS, Cauley CE.  J Gastrointest Surg. 2025 Mar;29(3):101963. 

Long-term outcomes of smartphone-delivered cognitive behavior therapy for body dysmorphic disorder: A one-year naturalistic follow-up.

Snorrason I, Hoeppner SS, Klare D, Weingarden H, Greenberg JL, Berger-Gutierrez RM, Bernstein EE, Vanderkruik RC, Harrison O, Wilhelm S.  Internet Interv. 2025 Jan 22;39:100803. 

Stress reactivity moderates the association between stressful life events and depressive symptoms in adolescents: Results from a population-based study.

Baltramonaityte V, Lussier AA, Smith ADAC, Simpkin AJ, Fairchild G, Dunn EC, Walton E.  J Affect Disord. 2025 Mar 15;373:28-34.